How to Build a World Class Anti-Aging Supplement Protocol with Dr. Sandra Kaufmann, M.D. EP 002

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Today's Guest

Dr. Sandra Kaufmann, M.D.

This week's guest is Dr Sandra Kaufmann. If you are interested in supplements & anti-aging...you will love Sandra Kaufmann!

Dr. Kaufmann began her academic career in the field of cellular biology, earning a Master’s Degree from the University of Connecticut in Tropical Ecology and Plant Physiology. Turning to medicine, she received her medical Degree at the University of Maryland, and completed a residency and fellowship at Johns Hopkins in the field of pediatric anesthesiology.

For the last five years she has been the Chief of Pediatric Anesthesia at the Joe DiMaggio Children’s Hospital, a nationally recognized center of excellence. Most recently, she was recognized as “Best in Medicine” by the American Health Council.

Her avid interest in the science of anti-aging began many years ago as an intense hobby. Utilizing her knowledge in cell biology, human pharmacology and physiology, this hobby has now become a main focus. The project represents years of non-clinical research leading to the first, ever, comprehensive theory of aging.

You'll Learn

  • The seven tenets of aging that encompass all of the presently known modes of cellular aging.
  • Supplements to combat aging in each of the seven tenets. 
  • Sandra's most commonly used Panacea strategy that consists of 5 supplements which cover all seven tenets of aging. 


The Seven Tenets of Aging

The Seven Tenets describe all of the presently known modes of cellular aging which contribute to the deterioration of tissues and organs over time.

1. DNA

Our DNA is our information depot. It’s packaged into chromosomes, which are protected by caps of non-coding DNA called telomeres. These telomeres shorten with each cell division and correlate with longevity. Concepts related to aging that fall under tenet 1 include epigenetic modification (like methylation), accumulation of DNA damage, and telomere shortening.

2. Mitochondria

Mitochondria are central to energy production in every cell. They’re also highly susceptible to oxidative damage as we age. When mitochondrial function declines, cellular health and longevity are at risk.

3. Cellular pathways

There are three key cellular pathways related to aging: 5’-AMP-activated protein kinase (AMPK),mammalian target of rapamycin (mTOR), and sirtuins. AMPK is an enzyme that regulates cellular energy metabolism. mTOR is an enzyme that regulates cell growth and the recycling of organelles. Sirtuins are a family of proteins that regulate energy efficiency, programmed cell death (apoptosis), and other cellular processes related to aging. These metabolic pathways can be turned on or off to influence cellular aging.

4. DNA and protein-repair mechanisms

Each cell has at least 105 DNA errors per day at baseline. There are four key repair mechanisms tokeep the damage in check. But with age, these repair mechanisms become stressed. And when errors in DNA and protein synthesis accumulate, cells can fail to replicate normally. I include autophagy in tenet 4 because it has to do with recycling old organelles and keeping the cells in good repair.

5. Immune system

The immune system acts as our security system, but there are three ways that it can also contribute to aging: through an increased rate of inflammation with age, a decreased ability to fight off infections, and a heightened risk of immune cells becoming cancerous and developing leukemia or lymphoma.

6. Individual cell requirements

Some cells replicate every few days, whereas others last a lifetime. Short-acting cells have a greater need for a steady pool of nutrients, whereas long-acting cells require more support for waste accumulation. There are stem cells, quiescent cells, senescent cells, etc. Each of these types of cells has different needs.

7. Waste management

As cells age, they accumulate more and more waste. One example is advanced glycation end products (AGEs) from the bonding of glucose with lipids and proteins. Another example is the pigment residue lipofuscin.

Dr Kaufmann's PANACEA Protocol for healthy aging

Below is a "done for you" comprehensive anti-aging protocol. Dr. Kaufmann’s PANACEA protocol combines ingredients to support all seven tenets of cellular aging. Dr. Kaufmann recommends that most people over the age of 40 incorporate the PANACEA protocol into their daily routine. I have personally used this protocol for years. 

Join my Thorne Dispensary & Wellevate Dispensary to get a discount on all the supplements listed below. Discount applied to every order.

If you live outside of the U.S., I suggest you reference Kaufmann's Master Chart and select supplements from the company Do Not Age (use code MCCAIN to save 10%) to cover all 7 tenets of aging. 

Thorne ResveraCel


Thorne's ResveraCel contains 3 supplements in the PANACEA protocol; Nicotinamide Riboside, Resveratrol& Quercetin. 

Dosing:  2 capsules/day



Klaire Labs L-Carnosine helps protect cells against free radicals and helps inhibit protein glycation.

Dosing:  500 mg - 2 times daily


Curcumin helps maintain a healthy inflammatory response in the joints, muscles, GI tract, liver, brain, and nerves

Dosing:  2 capsules/day

BioAstin Astaxanthin


Nature's strongest antioxidant to support mitochondria.

Dosing:  2 - 12 mg/day (Athletes 12 mg/day)  - Take with food

Note:  None of this is medical advice. Do your own research, and consult with your primary care physician before undertaking any therapies.

☕️ If you would like to support the Podcast, I love coffee…thank you! https://www.buymeacoffee.com/mccainfitness


Premium Nutritional Supplements

Get 20% off all Thorne supplements on every order with free shipping. Join my Thorne Dispensary

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